Among the 36 differentially expressed genes identified between T3 and T1, several have known associations with ccRCC: TRPM3, AQP1, FBP1, ITPKA, LOX, TUBB3, IGFBP1, ALDOB [18–25], other cancer types: FLRT3, ACE2, OGDHL, EYA1, STEAP3, GPRC5A, COMP, [26–32] or other renal diseases: MIOX, TINAG, ANGPTL3 [33–35]. The gene discussed is GPRC5A; the disease is cancer.