CD8A and neoplasm: While it is not enough only with the measurement of TC, IC PD‐L1‐positive expression was also proved to be a necessary predictive marker and associated with poor prognosis in several types of solid tumors.27 Xu‐Monette et al28 performed immunophenotypic profiling using a MultiOmyx immunofluorescence platform in 405 patients, and their results showed the critical role of the immune microenvironment and PD‐1 expression on CD8+ T cell and PD‐L1 expression on IC including tumor‐infiltrating T cell and macrophages both indicated inferior survival.