CBX2 and osteosarcoma: Additional, restoration of CBX2 expression significantly reversed the inhibitory effects of let‐7a on cell invasion (Figure 5G).Furthermore, we compared the expression of let‐7a between human osteosarcoma and normal osteoblast at both tissue and cellular levels, and observed that let‐7a level was lower in osteosarcoma tissues and cell lines than normal osteoblast (Figure 5H–I).