Elg1/ATAD5 forms a replication factor C (RFC)-like complex with Rfc2-5 (Bellaoui et al., 2003; Ben-Aroya et al., 2003; Kanellis et al., 2003), which is vital for genome stability, and, in mice and humans, appears to act as a tumour suppressor (Bell et al., 2011; Gazy et al., 2015; Johnson et al., 2016; Maleva Kostovska et al., 2016; Shemesh et al., 2017; Sikdar et al., 2009). Here, ATAD5 is linked to neoplasm.