Since these properties vary between bacterial proteins, and given the paucity of known SA T-cell antigens and the inadequacy of preclinical SA models of infection, we screened several proteins for their CD4+ T-cell-activating and IL-10-inducing capacities in human cells, by characterizing the response phenotypes (i.e., Th1, Th17 or Th22 lineages or immunosuppressive IL-10-producing CD4+ T cells) observed upon stimulation with these proteins. This evidence concerns the gene CD4 and infection.