The most accurate four-marker biosignature is comprised of sICAM-1, MPO, CXCL8, and IFN-γ diagnosed TBM with an AUC of 0.97 (95% CI, 0.92-1.00), corresponding to a sensitivity of 87.0% (20/23) (95% CI, 66.4-97.2%) and specificity of 95.8% (23/24) (95% CI, 78.9-99.9%). This evidence concerns the gene CXCL8 and meningeal tuberculosis.