In the present study, we initially found that EGb761 showed no toxic effect on PIG1 cells (data not shown), which was consistent with previous studies.10 The patients with vitiligo have inferior capacity against oxidative stress due to the lower activity of SOD and GSH‐Px.20, 21 Our study showed that EGb761 could significantly restore the activity of SOD and GSH‐Px in PIG1 cells under H2O2 treatment. Here, SOD1 is linked to vitiligo.