Previously, the data from circRNA expression profile revealed down‐regulation of circRNA circMTO1 (a circRNA derived from mitochondrial tRNA translation optimization 1 [MTO1] gene, hsa_circ_0007874) in HCC tissues.14 CircMTO1 has been demonstrated to play an inhibitory role in HCC progression. The gene discussed is MTO1; the disease is hepatocellular carcinoma.