RIPK3 and hydrops fetalis: Importantly, RIP3 showed strong expression in hearts of murine and human, which implied the importance of this protein for the function of myocardium.18, 19, 20 Recently, studies have shown that necroptosis played a vital role in ischaemia—and oxidative stress—induced myocardial remodelling and HF, which could be alleviated by RIP3‐depletion.18, 21 Based on these findings, we hypothesized that RIP3 gene variation may affect its expression and modify the susceptibility and prognosis of HF.