RIPK3 and melanoma: Necroptosis is a form of necrosis strictly regulated by distinct signalling pathway.12 Substantial evidence has demonstrated that RIPK1‐RIPK3‐MLKL axis represented the core components for tumour necrosis factor‐induced necroptosis both in human and mouse, which could be abolished by Receptor‐interacting protein kinase 3 (RIP3)‐depletion.12, 13, 14 Many pathological processes including malignant melanoma,15 intestinal tumourigenesis16 and Abdominal Aortic Aneurysms17 also have the participation of RIP3.