Moreover, participants carrying the rs3212247 CC genotype had higher plasma levels of RIP3 than those carrying the TT or TC genotype (p for trend = 0.02) in New York Heart Association (NYHA) class III HF group and the plasma RIP3 levels of NYHA III and IV groups were significantly higher compared with NYHA II and control groups, which suggest positive correlation between ripk3 level and severity of HF. Here, RIPK3 is linked to hydrops fetalis.