However, Javor et al found no difference of serum levels of RIP3 between NYHA class III‐IV patients and healthy individuals, which may be attributed to insufficient samples.36 Taking together, our findings indicated that rs3212247 could modify the progress of HF through disrupting the binding efficiency of SOX17 and reducing the expression of RIP3 (Figure 8). The gene discussed is SOX17; the disease is hydrops fetalis.