Recent studies showed that KPC1 ubiquitinates p105, leading to enhanced production of p50 but decreased levels of p65, which elicits suppression of tumor growth (Kravtsova‐Ivantsiv & Ciechanover, 2015; Kravtsova‐Ivantsiv et al., 2015). Here, NFKB1 is linked to neoplasm.