In addition, we found that the presence of LYVE-1-positive cells (lymphatic vessels) [20], MPO- positive cells neutrophils [21] and CD206-positive cells macrophages [22] was significantly increased in the orthotopic xenograft tumours of 44As3 in comparison to those of HSC-44PE (Supplementary Fig. S2a and S2b). The gene discussed is MRC1; the disease is neoplasm.