Previous studies by our group and others have shown that 1,25(OH)2D3 inhibits the Wnt/β-catenin signalling pathway in colon carcinoma cells mainly through the induction of VDR binding to β-catenin, which leads to the disruption of TCF/β-catenin complexes, and by the upregulation of E-cadherin that promotes β-catenin relocation from the nucleus to the cell membrane adherens junctions24,55. The gene discussed is VDR; the disease is colon carcinoma.