PGR and neoplasm: Upstream regulator analysis revealed significant enrichment in several mechanistic networks including SMARCA4, TNF, FOXO1, NFkB (complex), CAMP, Mek, CG, PPRC1, TGFB1, ERK, IL1B, PGR, and P38 MAPK (Supplementary Table 4).Taken together, our data revealed a significant increase in tumour growth, proliferation, and invasion, while functional categories associated with cell death were suppressed.