Currently, many important tumors lncRNA are known to exist in malignant tumors of many human organs, such as PCGEM1, ANRIL, DD3 in prostate cancer, HOTAIR in breast cancer, colorectal cancer, and laryngeal cancer, XIST in breast cancer, testicular cancer, MLAT1, Neat2 in early nonsmall cell lung cancer. This evidence concerns the gene HOTAIR and Familial prostate cancer.