S. epidermidis isolated from healthy individuals (N1, N2, N3, and N4) significantly elevated the levels of IFNL1 and IFNL2/3 mRNA in NHNE cells starting at 8 h after treatment, with maximum levels observed 24 h after infection (IFNL1 6.4 × 103, IFNL2/3 1.1 × 104, Fig. 2a). Here, IFNL2 is linked to infection.