Analysis revealed a significantly lower number of neurons with nuclear phosphorylated CREB (P-CREB+) in the NAWM of MS patients (18.3 ± 11.0%) compared to controls (72.5 ± 23.9%) (p = 3.4 × 10−02, Kruskal-Wallis with Dunn’s multiple comparisons test, Fig. 5b). This evidence concerns the gene CREB1 and myeloid sarcoma.