As a genetic effect of MTHFR rs1801133 and rs1801131 polymorphisms has been suggested in the susceptibility to colorectal cancer [6, 11, 33, 34], additional confounding factors such as smoking, drinking, age, sex, and patient features should be adjusted for further investigation of the MTHFR variants in the malignant conversion from colorectal polyp. This evidence concerns the gene MTHFR and colorectal cancer.