GJA1 and ischemic cardiomyopathy: Parajuli et al. [17] found that, in the heart specimens of patients with non-ischemic cardiomyopathy, patients with VA than those without VA had a reduction in the ratio of glutathione and oxidized glutathione with an increase in NADPH oxidase activity, accompanied by increased TRPM7 expression and Connexin 43 redistribution.