CXCL8 and neoplasm: Inflammatory pathway (NF-κB) also plays a major role in tumor stroma interaction [96] Lactate modulates tumor microenvironment by directly entering endothelial cells via MCT-1 and activating the phosphorylation/degradation of IκBα to stimulate the autocrine NF-κB/IL-8(CXCL8) pathway leading to cell migration, angiogenesis and tumor growth [97].