LDHA promotes cancer progression by regulating epithelial-to-mesenchymal transition (EMT) related genes such as Snail, Slug, E cadherin, N-cadherin, Fibronectin, Vimentin and by upregulating expression of stemness related genes such as OCT4, SOX2, Nanog and c-Myc [31]. The gene discussed is MYC; the disease is cancer.