One patient (patient 17 in Table 2) had invasive adenocarcinoma involving the urinary bladder diagnosed 11 years after an initial diagnosis of extensive anogenital EMPD; this bladder adenocarcinoma was likely related to the EMPD, as suggested by its immunophenotype (CK7+, CK20−, GCDFP15+). Here, PIP is linked to bladder adenocarcinoma.