EPCAM and Familial prostate cancer: For instance, Cell Search® (Menarini Silicon Biosystems, Bologna, Italy), the only U.S. Food and Drug Administration (FDA) approved method for enumerating CTCs in the peripheral blood of patients with breast, colorectal, or prostate cancer, relies on the specific antigen-antibody recognition of epithelial cell adhesion molecule (EpCAM) and magnetic-based separation for CTC enrichment.