TGFB1 and neoplasm: These TAMs, in turn, facilitate modulation of tumor microenvironment by initiating an immunosuppressive entity through the release of cytokines/chemokines and immunosuppressive factors such as IL-10, TGF-β, immune checkpoint modulators (Programmed death-1/programmed death ligand 1), Tregs, myeloid-derived suppressor cells (MDSCs) and type 2 helper (Th2) T cells.