As these MMPs are critical for ECM degradation as well enhancement of immune and signaling pathways such as TGF-β/Smad pathway, their upregulation indicates that the CRC exosomes play a vital role in promotion of adhesion as well as triggering of signaling pathways/inflammatory responses in cancer cells for metastasis and increased invasiveness [128]. This evidence concerns the gene TGFB1 and colorectal carcinoma.