In CRC, release of chemokines, cytokines and growth/angiogenic factors such as monocyte chemotactic protein-1 (CCL2), CCL3, CCL4, CCL5 (RANTES), CCL22 (macrophage-derived chemokine), CXC chemokines (CXCL8), Colony-stimulating factor-1 (CSF1) etc. polarizes these macrophages to the tumor tissue converting them into highly specialized cells known as tumor-associated macrophages (TAMs) [63]. Here, CCL4 is linked to neoplasm.