BCL2 and Cowden disease: Furthermore, there are few genes controlling autophagy such as Bcl-2 family (e.g., Beclin-1, Bcl-2, Bcl-xL) and the defect of genes cause expression of AIEC (e.g., NOD2, ATG16L1, IRGM) which therefore give implication that their mutations is one of the reasons that exacerbate CD.