In line with these and our findings, a recent study by Yang et al. demonstrated that postoperatively elevated VEGF serum levels correlate with a poor cancer-specific survival of PDAC patients, while elevated levels of CXCL-8/IL-8 are associated with a favorable prognosis, indicating that surgical resection of primary PDAC modulates the profile of inflammatory mediators, thereby impacting disease progression [17]. This evidence concerns the gene VEGFA and cancer.