By exploring databases reporting known alterations in cancer (cBioPortal; http://www.cbioportal.org and COSMIC (Catalogue of Somatic Mutations in Cancer); http://cancer.sanger.ac.uk) [20,21,22], we found several alterations that might influence the negative feedback loop in FGFR2 (Figure 5a). This evidence concerns the gene FGFR2 and cancer.