The neuroprotective effect of Nrf2 modulation in PD has been demonstrated [11] via its downstream expression products, including heme-oxygenase 1 (HO-1), superoxide dismutase 1 (SOD-1), and NAD(P)H dehydrogenase quinone 1 [12,13]. The gene discussed is HMOX1; the disease is Parkinson disease.