Taken together, it seems possible that silencing the expression of Sdc-1 in breast cancer cells could facilitate the binding of IFN-γ to its receptor on T cells, and abrogate the inhibitory effect of IL-6 on IFN-γ/IFN-γR signaling that would lead to an autoregulation of IFN-γ gene expression in T cells and induce Th1 polarization. The gene discussed is IFNGR1; the disease is breast cancer.