MR estimates were calculated using inverse‐variance weighted methods from 1044 cases and 1172 controls in a Chinese genome‐wide association study and validated by the Ovarian Cancer Association Consortium and Consortium of Investigators of Modifiers of BRCA1/2 studies with 29 396 cases and 68 502 controls of European ancestry. The gene discussed is BRCA1; the disease is ovarian carcinoma.