GnRH signaling, which plays a key role in the HPG axis,70 may influence ovarian cancer risk via various mechanisms.71, 72, 73 Rs2153127, as one of instrumental variables of AAM in our MR study, is indicated to be associated with the expression of LIN28B in pituitary (https://www.gtexportal.org/home/snp/rs2153127). The gene discussed is GNRH1; the disease is ovarian cancer.