Studies have shown that MAPKs pathway is essential in the progression of cancer, which do control cell growth, migration, proliferation, and differentiation.34, 35 MAPKs (ERK1/2, JNK and p38) are protein‐serine/threonine kinases, which could be activated through phosphorylation, beginning with the induction of MAPK kinase kinases (MAP3Ks) to adjust cell fates.36 Here, ERN1 is linked to cancer.