IL1B and cancer: IL‐1β is a multifunctional proinflammatory cytokine that has profound inflammatory and immune effects,17 and it plays a crucial role in the initiation and development of a wide range of inflammation‐associated cancers,18, 19, 20 especially GC.17, 18 IL‐1β is widely reported to promote gastric carcinogenesis and is associated with poor prognosis.21, 22, 23, 24 IL‐1β polymorphisms (IL‐1b‐511T and IL‐1b‐31C) can promote GC by boosting IL‐1β production and increasing circulating cytokine levels,17, 18 and Hp infection can induce IL‐1β expression.