TEADs are DNA‐binding proteins that can be activated by YAP1 and work as transcription factors.49 YAP1 has been demonstrated to promote tumorigenesis by activating TEAD in breast cancers, cholangiocarcinoma, and renal cell carcinoma.50, 51, 52 Moreover, TEADs were shown to be overexpressed in GC.53 In our study, disrupting the YAP1‐TEAD interaction interfered with the gastric tumor development process. This evidence concerns the gene YAP1 and gastric neoplasm.