EDA/EDB/‐containing cFn isoforms and TnC are also associated with solid tumors and metastatic cancers, wherein resident cancer cells activate the surrounding stromal fibroblasts, known as cancer‐associated fibroblasts (CAFs) (Erez et al., 2010; Kalluri, 2016; Gopal et al., 2017). Here, TNC is linked to metastatic malignant neoplasm.