Mantle cell lymphoma (MCL) is a specific type of highly invasive B cell malignant lymphoma, which accounts for 2% to 10% of non-Hodgkin lymphoma cases.[1–3] MCL originates from the inner layer of the follicular tissue without antigen-stimulated CD5+, CD23 negative cells.[4,5] MCL preferentially occurs in older men, with an average onset age of approximately 60 years old. This evidence concerns the gene CD5 and mantle cell lymphoma.