MCL typically has chromosome translocations such as t (11; 14) resulting in the insertion of the immunoglobulin heavy chain (IGHV) on chromosome 14q32 into oncogene cyclin D1 (CCND1) on chromosome 11q13, which is believed to be the major mechanism involved in MCL development.[5] In MCL patients, IGHV genes undergo mutations. This evidence concerns the gene CCND1 and mantle cell lymphoma.