In addition to regulating Integrin-based mechanotransduction, the action of DDR in CAFs also affects mRNA expression of collagen genes as well as collagen modifying enzymes such as lysyl oxidases and MMPs (Corsa et al., 2016) that can also contribute to altered matrix collagen fibers, tumor fibrosis and associated with enhanced metastasis (Cox et al., 2013). This evidence concerns the gene LOX and neoplasm.