DDR2 and neoplasm: When collagen organization within 5 microns of the tumor-stromal boundary was analyzed by focused ion beam scanning electron microscopy (FIB-SEM) there was less local collagen present, and the collagen fibers present were significantly thinner and more fragmented in Ddr2-/- FSP1cre tumors and ubiquitous Ddr2-/- tumors (Figure 5I; quantified in Figure 5J, also see Video 1, Video 2, and Video 3).