RASSF6 has been shown to be expressed in low amounts in HCC, and its overexpression correlates with decreased cell proliferation and invasion in vitro, as well as attenuated tumor growth in a rodent model.20 The inhibitory effects are described to be established through suppression of FAK phosphorylation, which in turn leads to decreased MMP2/9 expression.20 Our analysis confirms this finding, since we established the downregulation of RASSF6 in liver tissue extracted from liver tumors. Here, MMP2 is linked to neoplasm.