PML and neoplasm: We performed gene expression profiling of whole liver mRNA from WT animals, as well as from whole liver of PML−/−HCVtg mice that never developed a liver tumor (NTT), and compared these with gene expression profiling of whole liver mRNA from tumorous tissue (TT) and tumor surrounding tissue (TST) from PML−/−HCVtg mice that did develop liver masses (Figure 3A, Table S4).