PML and hepatocellular carcinoma: As of today, loss of PML has been described in numerous human cancers.15 In our in vivo approach, we could show that the deficiency of PML leads to increased HCC development in HCV‐transgenic mice when animals were treated with an established protocol of phenobarbital and diethylnitrosamine (DEN).13 Of note, HCV core protein targets PML‐NBs and inactivates the tumor suppressor function of PML through interference with the apoptosis‐induction of PML‐isoform IV in human hepatoma cells.12