Among patients with non‐squamous , univariate analyses showed that the EGFR mutation rate was significantly higher in females (P < 0.001), without a smoking history (P < 0.001), stage IV tumor (P = 0.002), brain metastases (P = 0.027), and pleural nodules metastases (P = 0.034) (Table 4). The gene discussed is EGFR; the disease is neoplasm.