Previous reports indicated an ALK rearrangement rate of 13.5% (19/141) among patients with NSCLC who were female, Asian, did not smoke or smoked relatively small amounts, and adenocarcinoma.16, 24, 25, 26 In the present study, 85.8% (973/1134) of the enrolled patients had adenocarcinoma, which may explain the relatively high ALK rearrangement rate. This evidence concerns the gene ALK and non-small cell lung carcinoma.