Shi et al.14 analyzed 747 patients with advanced NSCLC among a subset of patients from mainland China with an adenocarcinoma history as part of the PIONEER study, and found that the overall EGFR mutation rate was 50.2% among the 741 patients that were successfully genotyped, while the activating EGFR mutation rate was 48.0% (with 1.3% of patients showing combined activating and resistance mutations). This evidence concerns the gene EGFR and adenocarcinoma.