Additionally, the U2AF1c isoform is targeted by RNA surveillance for the introduction of a premature termination codon.37 In addition, studies have demonstrated that U2AF1a is essential for HeLa cell division and that knockdown of U2AF1a, alone or in conjunction with U2AF1b, has a more significant effect than knockdown of U2AF1b alone.24 Most studies have been demonstrated mutational analysis of U2AF1 splicing machinery in haematological malignancies and other tumours. Here, U2AF1 is linked to neoplasm.