MTA1 regulated p53 stability and decreased p53‐mediated apoptosis, which is also involved in p53 signalling pathways in prostate cancer (PCa) cells.41, 42 Furthermore, depletion of MTA1 increases levels of Res‐induced apoptosis and the accumulation of Bax in PCa cells.43 EIF3B knockdown decreases cell viability and increases apoptosis.44, 45 HNRNPD is a p53 target, and SNHG1 increases p53‐dependent apoptosis by impairing hnRNPC regulation of p53 activity.46, 47 In this study, the splicing patterns of these gene were found to be ESI, ISI, ATSS and ATTS. This evidence concerns the gene HNRNPD and Familial prostate cancer.