[65] These reports suggest that inhibitors of TNAP, such as adenosine, could be considered as potential preventive strategies in CAVD and supporting this hypothesis, we observed decreased serum and aortic root ALP activity in ApoE−/−LDLR−/− mice treated with adenosine deaminase inhibitor. Here, ALPL is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.