CALB1 and early-onset autosomal dominant Alzheimer disease: Accumulating evidence suggest that a deregulation of calcium signalling may play a major role in Alzheimer’s disease progression; CaBPS such as parvalbumin, calbindin and calretinin are upregulated in the hippocampus of 3-month-old APPswe/PS1dE9 transgenic mice, possibly to control cellular homoeostasis and synaptic plasticity, but losing cellular capacity to pathophysiological processes by the age of 12 months (Verdaguer et al. 2015).