We found that secretagogin expression significantly decreased with disease progression, paralleling TH loss typical already in the early phase of Alzheimer’s disease (Braak and Del Tredici 2012; Chan-Palay and Asan 1989; German et al. 1992; Kelly et al. 2017), which may reflect impaired cell function and activity. Here, SCGN is linked to early-onset autosomal dominant Alzheimer disease.