RORC and systemic lupus erythematosus: For example, in systemic lupus erythematosus (SLE) mice induced by pristane, feeding L. rhamnosus and Lactobacillus delbrueckii (L. delbrueckii) reduced the expression of RORγ mRNA, downregulated Th1 and Th17 cells, and decreased the levels of IFN-γ and IL-17 [60].