The DLK1-MEG3 imprinted locus is altered in a series of primary human tumors (myelomas, Wilms tumors, neuroblastomas, gliomas, see Huang et al., 2006; Kawakami et al., 2006; Jørgensen et al., 2013) and MEG3 gene expression is consequently lost in several tumor cell lines (Zhou et al., 2013). This evidence concerns the gene MEG3 and central nervous system cancer.