IGF2 and cancer: Indeed, some imprinted genes are tumor suppressors, such as MEG3 (Astuti et al., 2005; Zhou et al., 2013), KCNQ10T1 (Nakano et al., 2006) and CDKN1C (Sato et al., 2005), others promote proliferation, like IGF2 (Cui et al., 2003; Jelinic and Shaw, 2007; Lim and Maher, 2010; Monk, 2010, see Feinberg et al., 2006 for a more comprehensive list of cancer-associated imprinted transcripts).