One such example is IGF2, a promoter of proliferation that is associated with many types of cancer (Morison and Reeve, 1998; Cui et al., 2002, 2003; Kaneda and Feinberg, 2005; Rugg-Gunn et al., 2007) and with the overgrowth phenotype observed in Beckwith–Wiedemann syndrome (Tatton-Brown et al., 2013). The gene discussed is IGF2; the disease is cancer.