ICC harbors many genetic aberrations, including mutations in isocitrate dehydrogenase1/2 (IDH1/2), epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), KRAS, and BRAF (5, 6), as well as amplifications of Cyclin D1 (CCND1). Here, CCND1 is linked to intrahepatic cholangiocarcinoma.