Decreased airway hyperresponsiveness, total WBC, macrophages and eosinophils counts, levels of IL-4, IL-5 and IL-13 in BALF, serum levels of total IgE and OVA-specific IgE and IgG1Increased BALF level of IFN-γ and serum level of OVA-specific IgG2a. The gene discussed is IL5; the disease is airway hyperresponsiveness.