RYR2 and catecholaminergic polymorphic ventricular tachycardia: Studies have shown that mutations in RyR2 can cause catecholaminergic polymorphic ventricular tachycardia (CPVT), a heritable arrhythmogenic disease resulting in exertional syncope or sudden death (Priori et al., 2002; Priori et al., 2001).