P5CR1 is involved in amino acid synthesis and metabolism, and promoted the occurrence and development of malignant melanoma, prostate cancer, lung cancer, breast cancer, and other tumors (Cai et al., 2018; Ding et al., 2017; Ye, Wu & Wang, 2018; Zeng et al., 2017). Here, PYCR1 is linked to Familial prostate cancer.