ICOSL is typically located on APCs as well as in specific cancer cells such as glioma cells, melanoma, and hematologic neoplasm cells (Aspord et al., 2013; Martin-Orozco et al., 2010; Schreiner et al., 2003; Wang et al., 2012). This evidence concerns the gene ICOSLG and hematopoietic and lymphoid system neoplasm.