HER2 is a transmembrane receptor, the activation of which triggers PI3K/Akt and Ras/MAPK signaling pathways, contributing to tumor cell survival and proliferation (Ayoub, Al-Shami & Yaghan, 2019; Valabrega, Montemurro & Aglietta, 2007). This evidence concerns the gene AKT1 and neoplasm.