They are, therefore, critical for the detection of cancers as “dangerous” and initiating antigen-specific T-cell responses.4 Additionally, DC control the cytotoxic activity of, and interferon-gamma (IFNγ) production by, natural killer (NK) cells, which also serve important roles against cancer.5 However, tumors have evolved numerous mechanisms to suppress DC function and evade immune recognition.6,7. This evidence concerns the gene IFNG and cancer.