NOS3 and myocardial infarction: In conclusion, carrying the CC or CG genotypes, additionally the wild-type C allele of the rs7069102 single-nucleotide polymorphism, was associated with an increased risk of premature myocardial infarction, latter affecting SIRT1 and endothelial nitric oxide synthase protein expressions, irrespective of the underlying SIRT1 genotype.