SIRT1 and coronary artery disorder: In the present study, three candidate single-nucleotide polymorphisms of the SIRT1 gene (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 silent mutation) were investigated related to the pathogenesis of coronary artery disease through modifying SIRT1 protein expression [19].