The purpose of this study was to investigate the association between SIRT1 single-nucleotide polymorphisms (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 silent mutation) and the levels of SIRT1 and endothelial nitric oxide synthase expression, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) as well as common cardiovascular risk factors and major adverse cardiac events (MACEs) in young patients suffering from premature ST-elevation myocardial infarction (STEMI). Here, NOS3 is linked to ST Elevation Myocardial Infarction.