TP53 and osteosarcoma: Thus, the expression of MAGE-D1 proteins was significantly reduced in human breast carcinoma cells compared to untransformed immortal mammary epithelial cell lines, while the overexpression of MAGE-D1 in hepatocarcinoma, osteosarcoma, breast carcinoma and kidney epithelial cell lines led to the suppression of cell migration, invasion, adhesion and to the arrest of cell proliferation at the G1/S and G2/M stages through a p53-dependent pathway [61–63].