STAT5B and acute lymphoblastic leukemia: In this study, we also identified several additional cancer genes: STAT5B mutated at N642H which displays oncogenic aberrations in both T-cell lymphoma and T-ALL [27, 56, 57]; KDM7A a histone demethylase which may support aberrant activities of mutated histone H3 and of AUTS2 [58] while the effect of the mutation P897L remains unclear hitherto.