Axis inhibition protein 1 (AXIN1) is a multidomain scaffold protein that regulates the levels and localization of β-catenin during Wnt pathway activation and is involved in the genesis and progression of diseases like atrial septal defect, cryptorchidism, caudal duplication anomalies, breast cancer, non-small-cell lung cancer (NSCLC), hepatitis B virus-related hepatocellular carcinoma (HCC), colorectal cancer, and gastrointestinal cancer [14–22]. The gene discussed is AXIN1; the disease is hepatocellular carcinoma.